Coronavirus can also cause gastrointestinal complaints
Diarrhea is often underestimated as a possible Symptom of infection with the new Coronavirus SARS-CoV-2 so far, apparently. A recent study shows that, on average, more than ten percent of those Affected suffer from diarrhea. Also, the bacteria are excreted in the stool may be longer than, for example, when Sneezing or coughing.
“It will be investigated, reported on an increasing number of diarrhoeal diseases in connection with COVID-19” and “we have, therefore, the epidemiology, the clinical presentation and the molecular mechanisms (…) of SARS-CoV-2-associated diarrhoea,” explains the research team of Professor Laurent Peyrin-Biroulet of the Université de Lorraine. The researchers found that a significant proportion of Patients suffers from diarrhea, and also provide an explanation for the activity of the Virus in the digestive tract. Their results have been published in the journal “Clinical Gastroenterology and Hepatology”.
Diarrhea and intestinal 19 inflammation at COVID-
On the basis of an evaluation of the to March 2020 in scientific databases such as PubMed, EMBASE and Web of Science available studies, document the case and the mechanism of intestinal inflammation in patients with a confirmed diagnosis of SARS-CoV-2 infection, tried the researchers to determine how frequently complaints in the digestive tract actually are and what causes are eligible.
By case, at every tenth infection
In the clinical studies, the incidence rate of diarrhoea in COVID-19-cases, which lay between two and 50 per cent, according to the researchers. A compilation of the various studies have revealed an incidence rate of 10.4 per cent. Approximately every tenth COVID-19-disease is accompanied, therefore, also of discomfort in the digestive tract. The diarrhea may be preceded by respiratory symptoms (respiratory problems), but these also follow.
Why can cause the Virus in the intestinal damage?
Why the new Coronavirus, SARS-CoV can lead 2 in the digestive tract discomfort, according to a statement by the scientists on the basis of the receptor ACE2 (Angiotensin-converting enzyme 2) explain that the viruses use to latch on to the human cells. ACE2 will expressed “not only in the lungs, but also in the small intestine epithelia as well as in the upper esophagus, the liver and in the colon.” Furthermore, the binding affinity of SARS-and CoV-2 to ACE2 is particularly high.
Risk of infection by the fecal-oral route?
Not least, the researchers warn against a potential risk of infection by the fecal-oral route, as some studies have supplied evidence to suggest that the Coronavirus in the faeces over a longer period is more detectable than in nasopharyngeal swabs. In any case, should be considered for diarrhea that is currently also the possibility of a Coronavirus infection, particularly if accompanying symptoms such as cough, fever, shortness of breath, fatigue, or a loss of smell and sense of taste are added. (fp)